The D.M. Grant NMR Center supports research within the Chemistry Department and across campus.Below is a selection of recent publications that have utilized the Center.
Discovery, development, and utilization of transition metal catalyzed reactions to overcome obstacles in traditional synthetic approaches
Spahn, N. A., Nguyen, M. H., Renner, J., Lane, T. K., and Louie, J. (2017) Regioselective Iron-Catalyzed [2 + 2 + 2] Cycloaddition Reaction Forming 4,6-Disubstituted 2-Aminopyridines from Terminal Alkynes and Cyanamides. J. Org. Chem.82, 234–242.
The substitution patterns of the pyridine regioisomers were determined by a 1D-NOESY NMR experiment recorded at 400 MHz. The synthesis of other various products were confirmed by Successful synthesis of target product was confirmed by 1H and 13C NMR recorded at 300 and 400 MHz.
Staudaher, N., Lovelace, J., Johnson, M., Louie, J. (2017) Preparation of Aryl Alkyl Ketenes. Org. Synth.94, 1–15.
The synthesis strategy for various aryl alkyl ketenes was confirmed by 1H and 13C NMR recorded at 500 MHz.
Lahiri, N., Lotfizadeh, N., Tsuchikawa, R., Deshpande, V. V., and Louie, J. (2016) Hexaaminobenzene as a building block for a Family of 2D Coordination Polymers. J. Am. Chem. Soc. 19-22
Successful synthesis of target product was confirmed by 1H and 13C NMR recorded at 400 MHz.
Staudaher, N. D., Arif, A. M., and Louie, J. (2016) Synergy between Experimental and Computational Chemistry Reveals the Mechanism of Decomposition of Nickel-Ketene Complexes. J. Am. Chem. Soc.138, 14083–14091.
Various kinds of Ni(COD)2 reaction products were detected by 31P, 13C and 1H NMR spectroscopy recorded at 300, 400, or 500 MHz.
Thakur, A., Evangelista, J. L., Kumar, P., and Louie, J. (2015) An in Situ Approach to Nickel-Catalyzed Cycloaddition of Alkynes and 3-Azetidinones. J. Org. Chem.80, 9951–9958.
Nickel catalysis products were confirmed by 13C and 1H NMR spectroscopy recorded at 400 and 500 MHz.
Zhong, Y., Spahn, N. A., Stolley, R. M., Nguyen, M. H., and Louie, J. (2015) 3,5-Disubstituted 2-Aminopyridines Via Nickel-Catalyzed Cycloaddition of Terminal Alkynes and Cyanamides. Synlett26, 307–312.
NMR spectroscopy was used to determine identities of regioisomers and was recorded at 400 MHz.